Download Angiotensin and the Heart by Victor J. Dzau M.D. (auth.), Prof. Dr. med. H. Grobecker, PDF

By Victor J. Dzau M.D. (auth.), Prof. Dr. med. H. Grobecker, Prof. Dr. med. Gerd Heusch, Prof. Dr. med. B. E. Strauer (eds.)

ISBN-10: 3798509360

ISBN-13: 9783798509368

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Example text

However, Local and neurohumoral control of coronary blood flow 33 ACE-inhibitors did not improve regional blood flow to nonischemic (6, 68) and ischemic subendocardial layers (6, 68) during 12-60 min coronary occlusion in other studies using anesthetized (6) and conscious dogs (68). Even in the study claiming an anti-ischemic action of captopril, a reduction of subendocardial blood flow of the most ischemic zone was apparent (33). The finding that regional myocardial blood flow was improved in the nonischemic zones, but tended to decrease in the most ischemic subendocardial area, is suggestive of a collateral and transmural steal phenomenon.

Halperin JL, Faxon DP, Creager MA, Bass TA, Melidossian CD, Gavras H, Ryan TJ (1982) Coronary hemodynamic effects of angiotensin inhibition by captopril and teprotide in patients with congestive heart failure. Am J Cardiol 50:967-972 50. Heusch G (1990) a-adrenergic mechanisms in myocardial ischemia. Circulation 81:1-13 51. Heusch G, Deussen A, Thamer V (1985) Cardiac sympathetic nerve activity and progressive vasoconstriction distal to coronary stenoses: feed-back aggravation of myocardial ischemia.

Circulation 62:925-932 Local and neurohumoral control of coronary blood flow 41 86. Reimer KA, Jennings RB, Cobb FR, Murdock RH, Greenfield JC Jr, Becker LC, Bulkley BH, Hutchins GM, Schwartz RP Jr, Bailey KR, Passamani ER (1985) Animal models for protecting ischemic mycoardium: results of the NHLBI cooperative study. Comparison of unconscious and conscious dog models. Circ Res 56: 651-665 87. Rietbrock N, Thiirmann P, Kirsten R, Schneider W (1988) Anti-ischaemic effect of enalapril in coronary heart-disease.

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