Download Advances in Endogenous and Exogenous Opioids. Proceedings of by H. Takagi, Hiroshi Takagi, Eric J. Simon PDF

By H. Takagi, Hiroshi Takagi, Eric J. Simon

ISBN-10: 0444804021

ISBN-13: 9780444804020

Advances in Endogenous and Exogenous Opioids includes the court cases of the foreign Narcotic study convention (Satellite Symposium of the eighth foreign Congress of Pharmacology) held in Kyoto, Japan on July 26-30, 1981. The convention supplied a discussion board for discussing advances which have been made within the realizing of endogenous and exogenous opioids and tackled a big selection of subject matters starting from novel opiate binding websites selective for benzomorphan medications to the purification of opioid receptors and sequellae of receptor binding.

Comprised of 156 chapters, this booklet starts off with an research of the interplay of opioid peptides and alkaloid opiates with mu-, delta-, and kappa-binding websites. The reader is then systematically brought to biochemical facts for kappa and sigma opiate receptors; the motion of morphine and oxymorphone as partial agonists at the field-stimulated rat vas deferens; mechanisms of supersensitivity within the enkephalinergic approach; and houses of the solubilized opiate receptor from human placenta. next chapters discover the biosynthesis of opioid peptides in addition to their localization, unencumber, and degradation; physiological and pharmacological activities of opioids; and using analgesia in acupuncture. result of behavioral and scientific reports of endogenous and exogenous opioids also are provided, and the structure-activity relationships of opioids are examined.

This monograph can be of curiosity to scholars, practitioners, and researchers within the fields of psychiatry and pharmacology.

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Additional info for Advances in Endogenous and Exogenous Opioids. Proceedings of the International Narcotic Research Conference (Satellite Symposium of the 8th International Congress of Pharmacology) Held in Kyoto, Japan on July 26–30, 1981

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1980) Placenta, l9 327-336. 5. W. M. (1978) Br. J . Pharmac. 64, 607-614. , Tokyo MULTIPLE BINDING SITES FOR 3H-ETHYLKET0CYCLAZ0CINE ON THE LUMBO-SACRAL PORTION OF THE GUINEA-PIG SPINAL CORD B . A t t a l i , C. Gouarderes, Y. Audigier and J . Cros Laboratoire de Pharmacologie et de Toxicologie Fondamentales (CNRS), 205, route de Narbonne, 31 078 TOULOUSE Cedex, France. SUMMARY 3 H-ethylketocyclazocine binds to two classes of binding sites on guinea-pig spinal cord. The high a f f i n i t y sites correspond to the pharmacological characte­ r i s t i c s of the kappa receptors whereas the low a f f i n i t y s i t e s , also labelled by 3 H-etorphine, display pharmacological properties which are not related to the d i f f e r e n t types of opiate receptors previously characterized.

Each homogenate was preincubated at 37°C for 40 min, centrifuged at 30,000 g for 20 min, resuspended in buffer at 50 mg/ml, incubated for 40 min at 25°C, then placed on ice. 300 yl of each membrane preparation was incubated at 4°C for 2 hr with a 1 nM concentration of a tritiated ligand and 3-7 concentrations of unlabeled ligand. Total incubation volume was 500 yl. 5 ml cold buffer. bound radioactivity was assessed by scintillation counting. 2 WB (whole brain), ST (striatum), FC (frontal cortex), HC (hippocampus), HT (hypothalamus), MB (midbrain).

J. (1980) J. Exp. , 214, 209. S. B. (1980) J. Biol. , 255, (19). 9218. J. and Aiello, E. (1976) Science, 104, 539. H. and Dvorkin, B. (1980) Science, in press. ). , Tokyo OPIOID RECEPTORS ON RAT MAST CELLS Y. Yamasaki, 0. Shimamura and H. Ijichi Second Department of Medicine, Kyoto Prefectural University of Medicine. Kamikyo-ku, Kyoto 602, Japan. SUMMARY Morphine was shown to reverse the inhibitory effect of PGE-, on IgE-mediated 14 C-serotonin release from rat mast cells dose-dependently, naloxone-antagonizably and stereospecifically.

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