Download Advancements in Tumor Immunotherapy, Cancer Vaccines by H. Arnouk PDF

By H. Arnouk

ISBN-10: 9533079983

ISBN-13: 9789533079981

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Extra resources for Advancements in Tumor Immunotherapy, Cancer Vaccines

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Cancer Immunolology, Immunotherapy, Vol. 55, No. 12, (December 2006), pp. , & Escudier B. (2008). An adjuvant autologous therapeutic vaccine (HSPPC-96;vitespen) versus observation alone for patients at high risk of recurrence after nephrectomy for renal cell carcinoma; a multicentre, open-label, randomized phase III trial, The Lancet, Vol. 372, No. 9633, (July 2008), pp. W. (2009). Intravesical immunotherapy of superficial bladder cancer with chitosan/interleukin-12. Cancer Research, Vol. 69, No.

Of the 16 patients in the 25 μg cohort, one patient achieved complete response, three patients achieved partial response, and three patients achieved prolonged stabilization of disease (≥52 weeks). , 2003). Sixty metastatic renal cell cancer patients received 25 μg of HSPPC-96 weekly for four weeks and then biweekly until progression. A median of 18 weeks for progression free survival in combination with no serious adverse events observed makes HSPPC-96 a promising agent for disease stability. , 2008).

However, the responses to purified hPAP or GM-CSF proteins were not observed. Thus, the antigen-specific immuno-reactivity of Provenge observed in earlier studies was not confirmed in later studies. The safety and efficacy of sipuleucel-T was evaluated in two identically designed, randomised, double-blind, placebo-controlled phase III trials conducted in men with advanced prostate cancer. , 2006). Time to progression (TTP) was chosen as the primary end point. Patients were randomly assigned in a 2:1 ratio to receive sipuleucel-T therapy or placebo.

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